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Stage 5

Chronic Kidney Disease Stage 5 – End-stage renal failure (or late chronic renal insufficiency)

The terms end-stage renal failure and end-stage renal disease are used interchangeably, and the abbreviation ESRD is commonly used. Typically, patients will have kidney function in the area of 10-15% or so. These are the common symptoms you may experience at this stage (and some people may start experiencing some of these earlier):

Renal Failure Symptoms:

  • Anemia (may begin earlier than this)
  • Easy bleeding and bruising
  • Headache
  • Fatigue and drowsy feeling (more than normal or usual for you)
  • Weakness
  • Mental symptoms such as lowered mental alertness, trouble concentrating, confusion, seizures
  • Nausea, vomiting, and generally less desire to eat
  • Thirst
  • Muscle cramps, muscle twitching
  • Nocturia (night-time urination)
  • Numb sensation in the extremities
  • Diarrhea
  • Itchy skin, itchy eyes
  • Skin color changes (grayish complexion, sometimes yellowish-brownish tone)
  • Swelling and puffiness (more than you had while in advanced renal failure, and most likely in the feet and/or ankles)
  • Difficulty breathing (due to fluid in the lungs, anemia)
  • High blood pressure (with IgAN, you may already have had this since the early stages)
  • Decreased sexual interest
  • Changes in menstrual cycle (and difficulty getting pregnant)
  • Decreased urine output (however, you should be aware that some people with ESRD will continue to get rid of water as urine, but not wastes – therefore, the urine may be very clear and normal-looking, and some may have increased urine output rather than decreased)
  • Poor digestion (varying degrees of gastroparesis)

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